B-cell development: COX-1 joins the game

B - 1 B Cell Development 1

B - 1 B Cell Development 1 Richard

Centrosomes: PIDDosome Joins the Counting Game

Centrosome numbers are tightly regulated during the cell cycle. A new study shows that the PIDDosome prevents the propagation of cells carrying amplified centrosomes via p53 stabilisation and p21-mediated cell-cycle arrest, thus ensuring the maintenance of normal centrosome numbers.

Development: CLAVATA1 Joins the Club of Root Stem Cell Regulators

Stem cell maintenance and daughter cell differentiation is essential for root and shoot development. Genetic and physical interaction of the receptor-like kinases ACR4 and CLV1 bring a new player to the field of distal stem cell control in the primary root tip.

B - 1 Cell Development : Evidence for an Uncommitted Immunoglobulin ( Ig ) M 1 B Cell Precursor in B - 1 Cell Differentiation

Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subset. Analysis of anti-PtC (V H 12 and V H 12/V k 4) transgenic (Tg) mice indicates that exclusion from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement. This predicts that PtC-specific B-0 cells are generated, but subsequently eliminated by either apoptosis or differentiation...